Vaccines and vaccine components for inhibition of microbial...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/31 (2006.01) A61K 39/02 (2006.01) A61K 39/40 (2006.01) A61K 47/48 (2006.01) C07K 14/195 (2006.01) C07K 14/345 (2006.01) C07K 16/12 (2006.01) C07K 19/00 (2006.01) C12N 1/20 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2700129

The invention encompasses components from microbial cells which are useful for antibody production, including peptides, polypeptides comprising these peptides, polynucleotides which encode these peptides or polypeptides, and antibodies di-rected to these peptides, polypeptides, or polynucleotides. The invention also encompasses to expression vectors and host cells for producing these peptides, polypeptides, polynucleotides, and antibodies. The invention further encompasses methods and compo-sitions, especially vaccine compositions, for detecting, targeting, and inhibiting microbial cells, especially methanogen cells, using one or more of the disclosed peptides, polypeptides, polynucleotides, antibodies, expression vectors, and host cells.

L'invention porte sur des composants issus de cellules microbiennes qui sont utilisés pour la production d'anticorps, lesquels composants comprennent des peptides, des polypeptides comprenant lesdits peptides, des polynucléotides codant lesdits peptides ou polypeptides, et des anticorps dirigés contre lesdits peptides, polypeptides ou polynucléotides. L'invention se rapporte également à des vecteurs d'expression et à des cellules hôtes destinés à la production des peptides, polypeptides, polynucléotides et anticorps précités. L'invention concerne aussi des procédés et des compositions, en particulier des compositions vaccinales, qui permettent de détecter, cibler et inhiber des cellules microbiennes, notamment des cellules méthanogènes, au moyen d'un ou plusieurs des peptides, polypeptides, polynucléotides, anticorps, vecteurs d'expression et cellules hôtes de l'invention.

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