Vaccines comprising oligonucleotides having...

A - Human Necessities – 61 – K

Patent

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A61K 39/35 (2006.01) A61K 39/385 (2006.01)

Patent

CA 2600036

The present invention provides compositions comprising conjugate molecules that are structurally stable at a temperature of between about 2 degrees C and 8 degrees C. In some examples, a conjugate molecule comprises an antigen, such as an allergen. In some examples, a conjugate molecule comprises the Ragweed antigen Amb a 1. The present invention provides methods for making and using such compositions. Provided herein are methods for modulating an immune response in an individual comprising administration of a composition comprising a structurally stable conjugate molecule as described herein.

L'invention concerne des compositions contenant des molécules conjuguées structurellement stables à une température comprise entre environ 2 et 8 degrés C. dans certains modes de réalisation, la molécule conjuguée contient un antigène, tel qu'un allergène. Dans d'autres modes de réalisation, une molécule conjuguée contient un antigène Amb d'herbe à poux à 1°. Cette invention concerne également des procédé destinés à fabriquer et à utiliser ces compositions, ainsi que des procédés de modulation d'une réponse immunitaire chez un individu qui consiste à administrer une composition contenant une molécule conjuguée structurellement stable telle que décrite dans cette invention.

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