Vaccines containing avirulent phop-type microorganisms

Details Vaccines containing avirulent phop-type microorganisms Vaccines containing avirulent phop-type microorganisms

C - Chemistry, Metallurgy

12

N

167/135, 195/34.

C12N 1/20 (2006.01) A61K 39/112 (2006.01) C07K 14/255 (2006.01) C12N 9/02 (2006.01) C12N 9/16 (2006.01) C12N 15/62 (2006.01) C12N 15/65 (2006.01) C12N 15/74 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2013573

The phoP gene and its equivalents are of a type which have "global regulation of pathogenicity", i.e., they coordinately regulate a number of genes including those that encode bacterial virulence factors. In Salmonella, the phoP gene product also controls the expression of non-specific acid phosphatase from the phoN gene. A central feature of the invention are microorganisms which are avirulent as a result, in whole or in part, of a mutation in phoP, but which retain their immunogenicity. These cells are suitable as components of live vaccines.

Le gène phoP et ses équivalents appartiennent à un type qui comporte un mécanisme de « régulation globale de la pathogénicité », c'est-à-dire qu'ils régulent de façon coordonnée un certain nombre de gènes dont ceux qui codent des facteurs de virulence bactérienne. Dans Salmonella, le gène phoP contrôle aussi l'expression de la phosphotase acide non spécifique du gène phoN. Une caractéristique centrale de l'invention est le fait que des microorganismes deviennent avirulents, phénomène attribuable, en tout ou en partie, à une mutation dans le gène phoP, mais conservent leur immunogénicité. Ces cellules peuvent être utilisées comme constituants de vaccins vivants.

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