Vaccines for combatting septicemic bacteria

Details Vaccines for combatting septicemic bacteria Vaccines for combatting septicemic bacteria

C - Chemistry, Metallurgy

12

P

167/135, 195/128

C12P 21/00 (2006.01) A61K 39/02 (2006.01) A61K 39/108 (2006.01) A61K 39/112 (2006.01) C07K 14/24 (2006.01) C12N 1/21 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2029906

(57) Abstract The bacteria expressing iron-regulated outer membrane proteins of which certain are siderophore or transferrin receptors can be used in a vaccinal preparation. Said bacteria are obtained from a culture in a medium in which the iron content is reduced to a level for obtaining an increased expression of said proteins, and in particular of receptors, sufficient to induce, when said bacteria are used in a vaccine, the formation of antibodies preventing the specific recognition of siderophores by their receptors.

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