A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/015 (2006.01) A61K 39/39 (2006.01) A61K 47/18 (2006.01)
Patent
CA 2708716
The present invention relates to a component for a malaria vaccine comprising: a) an immunogenic particle RTS, S and/or b) an immunogenic particle derived from the CS protein of one or more P. vivax strains and S antigen from Hepatitis B and optionally unfused S antigen, or c) an immunogenic particle comprising RTS, CSV-S and optionally unfused S antigen, and d) a stabilizing agent comprising a stabilizing agent with at least one thiol functional group, or mixtures thereof. Methods for preparing the component, its use in medicine, particularly in the prevention of malarial infections, compositions/vaccines containing the component and use of the latter, particularly in therapy are also disclosed.
L'invention concerne un constituant de vaccin anti-malaria comprenant: (a) une particule immunogène RTS, S et/ou (b) une particule immunogène dérivée de la protéine CS d'une ou plusieurs souches de P. vivax et l'antigène S de l'hépatite B et éventuellement l'antigène N non fusionné ou (c) une particule immunogène comprenant RTS, CSV-S et l'antigène S éventuellement non fusionné et (d) un agent stabilisant consistant en un agent stabilisant comportant au moins un groupe thiol fonctionnel ou leurs mélanges. Elle concerne également des méthodes servant à préparer ce constituant, son utilisation médicale en particulier pour la prophylaxie d'infections malariennes, des compositions/vaccins contenant ce constituant et l'utilisation, en particulier thérapeutique, de ce dernier
Lemoine Dominique Ingrid
Wauters Florence Emilie Jeanne Francoise
Glaxosmithkline Biologicals S.a.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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