Vaccines for mycoplasma bovis and methods of use

Details Vaccines for mycoplasma bovis and methods of use Vaccines for mycoplasma bovis and methods of use

A - Human Necessities

61

K

A61K 39/02 (2006.01) A61K 39/00 (2006.01) A61K 39/39 (2006.01) A61P 31/00 (2006.01) A61P 31/04 (2006.01) A61P 37/04 (2006.01)

Patent

CA 2390613

The invention of novel, effective vaccines against Mycoplasma. bovis for use in cattle is described. These vaccines demonstrate no undesirable side effects and protect against M. bovis related disease, such as contagious mastitis, respiratory pneumonia, joint infections, keratoconjunctivitis and middle ear infections. The novel vaccines also lessen the effect of M. bovis infections on milk production, weight gain and animal health. Methods of diagnosing, characterizing and treating M. bovis infections as specific biotypes are also disclosed. Vaccine compositions made in accordance with the invention may be either of the attenuated or inactivated variety. Vaccines may also include antigens from other pathogens so as to provide a protective immunogenic response to diseases other than those caused by M. bovis.

L'invention concerne de nouveaux vaccins efficaces contre Mycoplasma bovis à utiliser chez le bétail. Ces vaccins ne présentent pas d'effets secondaires indésirables et protègent contre les maladies liées à Mycoplasma bovis, telles que la mammite contagieuse, la pneumonie respiratoire, les infections des articulations, la kératoconjonctivite et les infections de l'oreille moyenne. Les nouveaux vaccins selon l'invention réduisent aussi l'effet d'infections dues à Mycoplasma bovis sur la production de lait, la prise de poids et la santé de l'animal. L'invention concerne également des procédés pour le diagnostic, la caractérisation et le traitement des infections dues à Mycoplasma bovis sous forme de biotypes spécifiques. Les compositions vaccinales produites selon l'invention peuvent être soit du type atténué, soit du type inactivé. Les vaccins peuvent également contenir des antigènes d'autres agents pathogènes afin de fournir une réponse immunogène protectrice contre des maladies autres que celles provoquées par Mycoplasma bovis.

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