Vaccines for plague

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/62 (2006.01) A61K 9/107 (2006.01) A61K 9/127 (2006.01) A61K 9/50 (2006.01) A61K 35/66 (2006.01) A61K 39/02 (2006.01) A61K 47/34 (2006.01) A61P 31/04 (2006.01) A61P 37/04 (2006.01) C07K 14/24 (2006.01) C07K 19/00 (2006.01) C12N 1/21 (2006.01) C12N 15/31 (2006.01)

Patent

CA 2215203

A method of protecting a human or animal body from the effects of infection with Y. pestis is provided comprising administering to the body a vaccine including Yersinia pestis V antigen and Yersinia pestis F1 antigens or a protective epitopic part of each of these in a form other than whole Y. Pestis organisms. Preferably the antigens are administered in the form of a live vaccine or as recombinantly produced isolated and/or purified proteins. DNA encoding the whole or part of the F1 antigen and DNA encoding the whole or part of the V antigen may be used directly as a genetic vaccine.

Procédé de protection d'un sujet humain ou animal des effets de l'infection par Y. pestis, consistant à administrer au sujet un vaccin comprenant l'antigène V de Yersinia pestis V et les antigènes F1 de Yersinia pestis, ou une partie épitope protectrice de chacun d'eux, sous une forme autre que les organismes Y. Pestis entiers. De préférence, les antigènes sont administrés sous la forme d'un vaccin vivant, ou de protéines produites par recombinaison, isolées et/ou purifiées. L'ADN codant la totatité ou une partie de l'antigène F1 et de l'ADN codant la totalité ou une partie de l'antigène V peuvent être utilisés directement comme vaccin génétique.

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