Vaccines, immunotherapeutics and methods for using the same

Details Vaccines, immunotherapeutics and methods for using the same Vaccines, immunotherapeutics and methods for using the same

A - Human Necessities

61

K

A61K 39/00 (2006.01) A61K 31/7084 (2006.01) A61K 39/245 (2006.01) A61K 39/285 (2006.01) A61P 31/14 (2006.01) A61P 37/04 (2006.01) C12N 15/00 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2529051

Compositions, recombinant vaccines and live attenuated pathogens comprising one or more isolated nucleic acid molecules that encode an immunogen in combination with an isolated nucleic acid molecule that encodes an immunomodulator protein selected from the group consisting of: Fos, c-jun, Sp- 1, Ap-1, Ap-2, p38, p65Rel, MyD88, IRAK, TRAF6, IkB, Inactive NIK, SAP K, SAP- 1, JNK, interferon response genes, NFkB, Bax, TRAIL, TRAILrec, TRAILrecDRC5, TRAIL-R3, TRAIL-R4, RANK, RANK LIGAND, Ox40, Ox40 LIGAND, NKG2D, MICA, MICB, NKG2A, NKG2B, NKG2C, NKG2E, NKG2F, TAPI, TAP2 and functional fragments thereof are disclosed. Methods of inducing an immune response in an individual against an immunogen, using such compositions are disclosed.

L'invention concerne des compositions, des vaccins recombinants et des agents pathogènes atténués vivants comprenant une ou plusieurs molécules d'acides nucléiques isolées codant pour un immunogène en combinaison avec une molécule d'acide nucléique codant pour une protéine immunomodulatrice choisie dans le groupe constitué par Fos, c-jun, Sp-1, Ap-1, Ap-2, p38, p65Rel, MyD88, IRAK, TRAF6, IkB, NIK inactif, SAP K, SAP-1, JNK, des gènes de réponse aux interférons, NFkB, Bax, TRAIL, TRAILrec, TRAILrecDRC5, TRAIL-R3, TRAIL-R4, RANK, RANK LIGAND, Ox40, Ox40 LIGAND, NKG2D, MICA, MICB, NKG2A, NKG2B, NKG2C, NKG2E, NKG2F, TAPI, TAP2 et des fragments fonctionnels correspondants. L'invention concerne également des méthodes destinées à induire une réponse immunitaire chez un individu contre un immunogène au moyen de ces compositions.

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