Vaccines including antigen from four strains of influenza virus

Details Vaccines including antigen from four strains of influenza virus Vaccines including antigen from four strains of influenza virus

A - Human Necessities

61

K

A61K 39/145 (2006.01) A61P 31/16 (2006.01)

Patent

CA 2671629

Vaccines of the invention include at least four influenza virus strains. In some embodiments, the vaccines are produced in cell culture rather than in eggs. In some embodiments, the vaccines include an adjuvant. In some embodiments, the vaccines are not split or whole virion vaccines, but are live or purified glycoprotein vaccines. In some embodiments, the vaccines contain substantially the same mass of hemagglutinin (HA) for each of the influenza virus strains. In some embodiments, the four strains will include two influenza A virus strains and two influenza B virus strains ('A-A-B-B'). In other embodiments, the four strains will include three influenza A virus strains and one influenza B virus strain ('A-A-A-B').

L'invention concerne des vaccins comprenant au moins quatre souches du virus grippal. Selon certains modes de réalisation, les vaccins sont produits par culture cellulaire plutôt que dans des AEufs. Selon certains modes de réalisation, les vaccins comprennent un adjuvant. Selon certains modes de réalisation, les vaccins ne sont pas des vaccins à virion entier ou fragmenté, mais des vaccins à glycoprotéine vivante ou purifiée. Selon certains modes de réalisation, les vaccins contiennent sensiblement la même masse d'hémoglutinine (HA) pour chacune des souches de virus grippal. Selon certains modes de réalisation, les quatre souches comprennent deux souches de virus grippal A et deux souches de virus grippal B (A-A-B-B). Selon certains modes de réalisation, les quatre souches comprennent trois souches de virus grippal A et une souche de virus grippal B (A-A-A-B).

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