Vaccines with enhanced immune response and methods for their...

A - Human Necessities – 61 – K

Patent

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A61K 39/39 (2006.01) A61K 9/00 (2006.01) A61K 9/127 (2006.01) A61K 39/00 (2006.01) A61K 39/29 (2006.01) A61P 15/00 (2006.01)

Patent

CA 2428103

The present invention is concerned with vaccines and their preparation. An effective long-term immune response, especially in mammals, can be produced using a vaccine comprising an antigen encapsulated in liposomes, a suitable adjuvant and a carrier comprising a continuous phase of a hydrophobic substance. The vaccine is particularly effective in eliciting the production of antibodies that recognize epitopes of native proteins.

L'invention concerne des vaccins et leur préparation. Une réponse immunitaire à long terme efficace, spécialement chez les mammifères, peut être produite au moyen d'un vaccin comprenant un antigène encapsulé dans des liposomes, un adjuvant approprié et un véhicule comportant une phase continue d'une substance hydrophobe. Le vaccin est particulièrement efficace dans l'induction de la production d'anticorps reconnaissant les épitopes de protéines natives.

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