Vaccinia virus mva-e3l-knock-out-mutants and use thereof

Details Vaccinia virus mva-e3l-knock-out-mutants and use thereof Vaccinia virus mva-e3l-knock-out-mutants and use thereof

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 38/21 (2006.01) A61K 38/48 (2006.01) A61K 39/00 (2006.01) C12N 7/00 (2006.01) C12N 7/04 (2006.01) C12N 15/863 (2006.01)

Patent

CA 2459754

The present invention relates to mutant MVA vaccinia viruses, which are used for the generation of recombinant MVA viruses, as well as host cells, which have been infected with these mutant MVA viruses. The present invention further relates to DNA-vector constructs, and a method for the generation of recombinant MVA by using the mutant MVA viruses and the DNA-vector constructs. The mutant MVA vaccinia viruses of the present invention are characterized in that the MVA ORF 050L gene or a functional part thereof has been inactivated in the viral genome.

La présente invention concerne des virus de la vaccine à mutation MVA, utilisés pour produire des virus MVA recombinants, ainsi que des cellules hôtes qui ont été infectées par ces virus à mutation MVA. L'invention concerne également des constructions de vecteurs ADN et un procédé pour produire un vaccin MVA recombinant au moyen des virus à mutation MVA et des constructions de vecteurs ADN. Les virus de la vaccine à mutation MVA selon la présente invention se caractérisent en ce que le gène MVA ORF 050L, ou une partie fonctionnelle de celui-ci, a été inactivé dans le génome viral.

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