Vagal afferent neurons as targets for treatment

Details Vagal afferent neurons as targets for treatment Vagal afferent neurons as targets for treatment

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2597030

A method of identifying a compound capable of reducing or preventing prolonged sensory neuron hyper-excitability comprising the steps of: (a) administering the compound to an experimental non-human animal having prolonged sensory neuron hyper-excitability; (b) generating an expression profile of the genes modulated in the Nodose Ganglia (NG) of the animal of step (a); (c) comparing the expression profile obtained in (b) with the expression profile of a corresponding panel of genes expressed in the NG of an experimental non-human animal having no prolonged sensory neuron hyper-excitability; wherein a positive correlation of the expression profiles is indicative that the compound is capable of reducing or preventing prolonged sensory neuron hyper- excitability in NG.

L'invention concerne une méthode d'identification d'un composé permettant de réduire ou de prévenir une hyperexcitabilité neuronale sensorielle prolongée. Cette méthode comprend les étapes consistant à: (a) administrer le composé à un animal non humaind' expérimentation présentant une hyperexcitabilité neuronales sensorielle prolongée; (b) générer un profil d'expression des gènes modulés dans le ganglion noueux (NG) de l'animal de l'étape (a); (c) comparer le profil d'expression obtenu à l'étape (b) avec le profil d'expression d'un panel correspondant de gènes exprimés dans le NG d'un animal non humain d'expérimentation présentant une hyperexcitabilité neuronale sensorielle prolongée. Une corrélation positive des profils d'expression indique que le composé peut réduire ou prévenir l'hyperexcitabilité neuronale sensorielle prolongée dans le NG.

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