Vaginal delivery of bisphosphonates

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/663 (2006.01) A61K 9/00 (2006.01) A61K 31/675 (2006.01) A61P 19/08 (2006.01) A61P 19/10 (2006.01) A61P 35/00 (2006.01) A61F 6/08 (2006.01) A61F 13/20 (2006.01) A61K 47/38 (2006.01) A61M 31/00 (2006.01)

Patent

CA 2416122

Devices, methods, and compositions for vaginal delivery of bisphosphonates. A targeted site delivery of bisphosphonates to the vagina using a medicated intravaginal device comprising a bisphosphonate composition formulated for transvaginal delivery. A method for treatment of osteoporosis and related bone and skeleton diseases, for prevention of bone breakdown and loss of bone mass and strength by intravaginal administration of bisphosphonates to the vagina and transvaginal delivery of bisphosphonates to the general circulation.

L'invention concerne des dispositifs, des méthodes et des compositions servant à l'administration de diphosphonates par voie vaginale. Elle concerne également l'administration de diphosphonates sur un site cible du vagin au moyen d'un dispositif médicamenteux intravaginal comprenant une composition de diphosphonates préparée à des fins d'administration transvaginale. L'invention concerne en outre une méthode de traitement de l'ostéoporose et de maladies osseuses ou du squelette apparentées, de prévention de la dégradation osseuse ou de la perte de masse et de résistance osseuses par administration intravaginale de diphosphonates, et par administration transvaginale de diphosphonates destinés à la circulation générale.

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