Vaginal suppository vaccine for urogenital infections

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/116 (2006.01) A61K 9/02 (2006.01)

Patent

CA 2302505

This invention is directed to a suppository-based vaccine delivery system for immunizing against urogenital infectious disease in humans and a method for treating same. More particularly, this invention is directed to a suppository- based vaccine delivery system for the prophylaxis against urogenital infectious diseases, such as urinary tract infections. The suppository-based vaccine delivery system is comprised of a vaccine comprised of inactivated bacteria which originate from cultures of 8 to 14 uropathogenic bacteria strains of species: Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Proteus morganii, and Streptococcus faecalis; and polyethylene glycol suppository base; wherein the suppository is adapted to be inserted into a bodily orifice of a human so as to allow the suppository to be in contact with tissue of the bodily orifice to facilitate transfer of suppository material therethrough.

L'invention concerne un système d'administration de vaccin sous forme d'ovule destiné à immuniser des êtres humains contres les maladies infectieuses génito-urinaires, ainsi qu'une méthode de traitement de ces maladies. En particulier, l'invention concerne un système d'administration de vaccin sous forme d'ovule servant de prophylaxie contre les maladies infectieuses génito-urinaires, telles que les infections des voies urinaires. Le système d'administration de vaccin sous forme d'ovule est constitué d'un vaccin comprenant des bactéries inactivées provenant de cultures de 8 à 14 souches de bactéries uropathogènes des espèces suivantes: Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Proteus morganii, et Streptococcus faecalis; et d'une base suppositoire polyéthylène glycol; ledit ovule étant conçu pour être introduit dans un orifice corporel d'un être humain de manière que l'ovule puisse être au contact des tissus de l'orifice corporel et faciliter le transfert de matière suppositoire à travers lesdits tissus.

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