Val27, ala29-salmon calcitonin

Details Val27, ala29-salmon calcitonin Val27, ala29-salmon calcitonin

C - Chemistry, Metallurgy

07

K

530/7.36

C07K 14/585 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1041088

ABSTRACT OF THE DISCLOSURE This invention relates to a polypeptide of the formula Image [I] and acid addition salts and complexes thereof. The polypeptide of the formula [I] has serum calcium reducing activity, and as tests upon rats have shown, it has an activity of 3700 - 6000 MRC units for serum calcium reducing activity. It has an activity which is fifteen times higher than that of human calcitonin and sheep calcitonin and twenty times higher than that of porcine or cattle calcitonin. The said activity is the same or higher as compared with the most active of known salmon calcitonin.

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