A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/263, 167/269
A61K 31/19 (2006.01) A61K 9/20 (2006.01) A61K 31/16 (2006.01) A61K 31/20 (2006.01) A61K 31/22 (2006.01)
Patent
CA 2009890
The invention relates to controlled release pharmaceutical compositions. These contain as active ingredient valproic acid, a salt of valproic acid, an ester of valproic acid, Valpromide, or any other pharmaceutically acceptable deriv- ative of valproic acid which upon administration to humans provides a serum level of valproic acid, in combination with an additive which is selected from physiologically accept- able polymeric substances and from native proteins. The active ingredient is usually in the range of from 10 to 80 weight per cent. The novel pharmaceutical compositions are prepared by applying a high pressure to a mixture of the ingredients. They result in a prolonged serum level of the active ingredient.
Bialer Meir
Dubrovsky Joseph
Friedman Michael
Rubinstein Avraham
Abbott Laboratories
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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