Valproic acid analogues and pharmaceutical compositions thereof

Details Valproic acid analogues and pharmaceutical compositions thereof Valproic acid analogues and pharmaceutical compositions thereof

C - Chemistry, Metallurgy

07

C

C07C 53/21 (2006.01) A61K 31/185 (2006.01) A61P 25/00 (2006.01) C07C 53/23 (2006.01) C07C 57/02 (2006.01) C07C 57/03 (2006.01) C07C 57/26 (2006.01) C07C 57/52 (2006.01) C07C 59/135 (2006.01) C07C 59/21 (2006.01) C07C 69/587 (2006.01) C07C 69/608 (2006.01) C07C 69/65 (2006.01)

Patent

CA 2508855

Analogues of valproic acid useful in treating neuroaffective disorders including convulsions, bipolar disorder, and migraine headache are disclosed. The analogues are halide substituted analogues, cyclic analogues, and conjugated diene analogues of valproic acid. Pharmaceutical compositions or prodrugs containing the analogues or pharmaceutically acceptable salts thereof are disclosed. Methods of making the compounds and treating mammals with neuroaffective disorders are also disclosed.

L'invention concerne des analogues de l'acide valproïque, utiles pour traiter des troubles neuropsychiatriques tels que les convulsions, la maladie affective bipolaire et la migraine. Lesdits analogues sont des analogues substitués d'halogénure, des analogues cycliques et des analogues de diènes conjugués de l'acide valproïque. L'invention se rapporte également à des compositions pharmaceutiques ou à des promédicaments contenant lesdits analogues, ou à des sels pharmaceutiquement acceptables de ces derniers. L'invention a enfin trait à des procédés de production desdits composés, et à des méthodes permettant de traiter des mammifères atteints de troubles neuropsychiatriques.

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