A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/19 (2006.01) A61P 5/02 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2414967
The present invention relates to the use of the drug valproic acid and derivatives thereof as inhibitors of enzymes having histone deacetylase activity. The invention also relates to the use of those compounds for the manufacture of a medicament for the treatment of diseases which are associated with hypoacetylation of histones or in which induction of hyperacetylation has a beneficial effect for example by induction of differentiation and/or apoptosis in transformed cells.
La présente invention concerne l'utilisation de l'acide valproïque médicament et de ses dérivés en tant qu'inhibiteurs d'enzymes ayant une activité histone déacétylase, ainsi que l'utilisation de ces mêmes composés pour préparer un médicament destiné à traiter les maladies qui sont associées à l'hypoacétylation des histones ou dans lesquelles l'induction de l'hypoacétylation produit un effet bénéfique par l'induction de la différentiation et/ou de l'apoptose dans des cellules transformées.
Gottlicher Martin
Groner Bernd
Heinzel Thorsten
Herrlich Peter
Georg-Speyer-Haus
Goudreau Gage Dubuc
LandOfFree
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