Valproic and (e)-2-valproenoic acid derivatives, processes...

Details Valproic and (e)-2-valproenoic acid derivatives, processes... Valproic and (e)-2-valproenoic acid derivatives, processes...

C - Chemistry, Metallurgy

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C

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C07C 69/28 (2006.01) C07C 69/533 (2006.01) C07D 207/404 (2006.01) C07D 213/30 (2006.01) C07D 317/30 (2006.01) C07D 317/40 (2006.01)

Patent

CA 1331186

- 21 - Abstract: VALPROIC AND (E)-2-VALPROENOIC ACID DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSI- TIONS THEREFROM 2-Propyl-2-pentanoic acid (valproic acid) esters and (E)-2-propyl-2-pentenoic acid [(E)-2-valproenoic acid] esters surprisingly proved to have valuable properties, in that they show anticonvulsive and antiepileptic activities comparable with those of valproic acid, as well as an im- proved bioavailability and a markedly reduced toxicity.

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