C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/00 (2006.01) A61K 31/28 (2006.01) A61K 31/555 (2006.01) C07D 309/38 (2006.01)
Patent
CA 2291775
Organovanadium complexes, and more specifically hydroxyoxovanadium(V), µ- oxo dimeric oxovanadium(V) and cis-dioxovanadium(V) complexes, are provided. The complexes may be formulated into a pharmaceutical composition. The complexes and/or compositions may be used in the treatment of a variety of disease states, including use as anti-proliferative and/or anti-metastatic agents and/or to treat drug resistant tumors and/or to methods of reducing the ability of tumors to metastasize and/or for the treatment of diabetes, arthritis, multiple sclerosis, diseases involving passageways of the body, and autoimmune diseases including but not limited to psoriasis and lupus.
L'invention se rapporte à des complexes d'organovanadium et, plus particulièrement, à des complexes d'hydroxyoxovanadium (V), de µ-oxo dimère oxovanadium (V) et de cis-dioxovanadium. Ces complexes peuvent être formulés sous forme d'une composition pharmaceutique. Ces complexes et/ou compositions peuvent être utilisés dans le traitement d'une pluralité d'états pathologiques, notamment en tant qu'agents anti-prolifératifs et/ou anti-métastatiques, et/ou en vue de traiter des tumeurs résistant aux médicaments. L'invention concerne également des procédés permettant de réduire l'aptitude des tumeurs à métastaser et/ou de traiter du diabète, l'arthrite, la sclérose en plaques, des maladies impliquant des voies du corps humain, et des maladies auto-immunes, notamment le psoriasis ou le lupus, mais pas uniquement.
Lemieux Pierre
Toleikis Philip
Zhang Zaihui
Angiotech Pharmaceuticals Inc.
Gowling Lafleur Henderson Llp
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