A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/555 (2006.01) A61K 31/28 (2006.01) A61K 31/327 (2006.01) A61K 31/44 (2006.01) A61K 31/444 (2006.01) A61K 31/4745 (2006.01) A61K 33/24 (2006.01) A61K 38/28 (2006.01)
Patent
CA 2280249
This invention describes the use of vanadium compounds as anti-angiogenics. Biperoxovanadium compounds are preferred since they are more potent than the "oxo" compounds and less toxic than the latter. Anti-angiogenic activity has been verified in vitro against human umbilical vascular endothelial cells as well as ex ovo in the chicken chorioallantoic assay membrane. The vanadium compounds also inhibit the endothelin plasmatic increase after insulin stimulation in rats. It is proposed that vanadium compounds are valuable therapeutically active anti-angiogenics by acting inter alia either on the proliferation of endothelial cells, or the secretion of endothelins, or both.
Batistini Bruno Joseph
Doillon Charles
Faure Robert
Posner Barry
Savard Pierre
Batistini Bruno Joseph
Doillon Charles
Faure Robert
Goudreau Gage Dubuc
Posner Barry
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