Vancomycin formulations having reduced amount of histamine

Details Vancomycin formulations having reduced amount of histamine Vancomycin formulations having reduced amount of histamine

C - Chemistry, Metallurgy

12

P

C12P 21/04 (2006.01) A61K 31/785 (2006.01)

Patent

CA 2627821

A time-released formulation of vancomycin. The invention also includes a vancomycin composition having a reduced level of histamine and a process for reducing the level of histamine in a vancomycin composition. The invention also includes a pharmaceutical composition containing vancomycin that reduces the incidence of Red Man Syndrome, phlebitis, and hypotension. The invention further includes a histamine-free growth media that supports growth of Amycolatopsis orientalis and the fermentation of vancomycin.

L'invention concerne une formulation de vancomycine à libération régulée. L'invention concerne également une composition de vancomycine à teneur réduite en histamine et un procédé de réduction du niveau d'histamine dans une composition de vancomycine. L'invention concerne également une composition pharmaceutique contenant de la vancomycine qui réduit l'incidence du syndrome de l'homme rouge, de la phlébite, et de l'hypotension. L'invention concerne en outre un milieu de croissance exempt d'histamine supportant la croissance d'Amycolatopsis orientalis et la fermentation de vancomycine.

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