Vanilloid analogues containing resiniferatoxin...

C - Chemistry – Metallurgy – 07 – C

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Details

C07C 235/34 (2006.01) A61K 31/165 (2006.01) A61K 31/17 (2006.01) C07C 335/12 (2006.01)

Patent

CA 2363531

The present invention is related to new vanilloid analogues containing resiniferatoxin pharmacophores, pharmaceutical compositions comprising such analogues, and their uses as vanilloid receptor agonists and potent analgesics. The present invention provides a pharmaceutical composition for treating acute, chronic, inflammatory or neuropathic pains or for treating bladder hypersensitivity.

L'invention concerne des nouveaux analogues de vanilloïdes contenant des pharmacophores de résinifératoxine, des compositions pharmaceutiques comprenant lesdits analogues, ainsi que leurs utilisations en tant qu'agonistes du récepteur de vanilloïde et analgésiques puissants. L'invention porte également sur une composition pharmaceutique pour le traitement de douleurs aiguës, chroniques, inflammatoires ou neuropatiques ou pour le traitement de l'hypersensibilité de la vésicule.

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