Vanilloid receptor ligands and their use in treatments

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 319/16 (2006.01) A61K 31/357 (2006.01) A61K 31/404 (2006.01) A61K 31/4184 (2006.01) A61K 31/428 (2006.01) A61K 31/4709 (2006.01) A61P 29/00 (2006.01) C07D 209/08 (2006.01) C07D 215/38 (2006.01) C07D 235/06 (2006.01) C07D 277/82 (2006.01) C07D 405/12 (2006.01) C07D 407/12 (2006.01) C07D 417/12 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2553966

bis-Bicyclic amides and derivatives thereof and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

L'invention concerne des amides bis-bicycliques et des dérivés de ceux-ci et des compositions renfermant ceux-ci permettant de traiter les douleurs inflammatoires et neuropathiques aiguës, les douleurs dentaires, les céphalées générales, la migraine, la céphalée vasculaire de Horton, les syndromes vasculaires mixtes et les syndromes non vasculaires, la céphalée de tension, l'inflammation générale, l'arthrite, les maladies rhumatismales, l'arthrose, les troubles intestinaux inflammatoires, les troubles oculaires inflammatoires, les troubles de la vessie inflammatoires ou instables, le psoriasis, les problèmes de peau à composantes inflammatoires, les états inflammatoires chroniques, les douleurs inflammatoires et l'hyperalgie et l'allodynie associées, les douleurs neuropathiques et l'hyperalgie et l'allodynie associées, les douleurs neuropathiques diabétiques, la causalgie, les douleurs persistantes sympathiques, les syndromes de désafférentation, l'asthme, la dégradation ou le dysfonctionnement du tissu épithélial, l'herpès simplex, les troubles de la motilité viscérale dans des régions du système respiratoire, génito-urinaire, gastro-intestinal ou vasculaire, les blessures, les brûlures, les réactions cutanées allergiques, le prurit, le vitiligo, les troubles gastro-intestinaux généraux, l'ulcère gastrique, les ulcères duodénaux, la diarrhée, les lésions gastriques induites par des agents nécrosants, la croissance capillaire, la rhinite vasomotrice ou allergique, les troubles bronchiques ou les troubles de la vessie.

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