Variable domains of camelid heavy-chain antibodies directed...

Details Variable domains of camelid heavy-chain antibodies directed... Variable domains of camelid heavy-chain antibodies directed...

C - Chemistry, Metallurgy

07

K

C07K 16/30 (2006.01) A61K 39/395 (2006.01)

Patent

CA 2730268

The present invention relates to the use of variable domains of camelid heavy- chain antibodies (VHH domains) di-rected against an intracellular target and having an isoelectric point of at least 8.5, for targeting said intracellular target or for the preparation of a peptide vector. Particularly, it concerns VHH domains directed against a glial fibrillary acidic protein and uses thereof for preparing therapeutic or diagnostic agents.

La présente invention concerne l'utilisation de domaines variables d'anticorps de camélidé à chaîne lourde (domaines VHH) dirigés contre une cible intracellulaire et ayant un point isoélectrique d'au moins 8,5, pour cibler ladite cible intracellulaire ou pour la préparation d'un vecteur peptidique. En particulier, l'invention concerne les domaines VHH dirigés contre une protéine acide fibrillaire gliale et leurs utilisations dans la préparation d'agents thérapeutiques ou de diagnostic.

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