Variable region fusion peptides that form effector complexes...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 19/00 (2006.01) C07K 16/40 (2006.01) C12N 9/00 (2006.01) C12N 9/04 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2309763

The fusion polypeptides of this invention contain a variable region sequence linked to an effector sequence. The polypeptides do not form stable complexes in solution, except in the presence of an antigen. Upon contacting with the antigen, the two variable region sequences bind together, which in turn drives the effector sequences into juxtaposition. Complementation of one effector sequence with the other provides an effector function, such as enzyme activation, which has a number of therapeutic or diagnostic applications.

Les polypeptides de fusion faisant l'objet de cette invention contiennent une séquence de région variable liée à une séquence effectrice. Ces polypeptides ne forment pas de complexes stables en solution, sauf en présence d'un antigène. Lors du contact avec l'antigène, les séquences de région variable se fixent l'une à l'autre, ce qui a pour conséquence de mettre en juxtaposition les séquences effectrices. L'association d'une séquence effectrice avec l'autre fournit une fonction effectrice, par exemple une activation enzymatique, qui peut servir à un grand nombre d'applications thérapeutiques ou diagnostiques.

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