Variant activin receptor polypeptides and uses thereof

Details Variant activin receptor polypeptides and uses thereof Variant activin receptor polypeptides and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/71 (2006.01) C12N 5/10 (2006.01) C12N 15/861 (2006.01)

Patent

CA 2679841

The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and proteins. Compositions and methods for treating muscle-wasting and other diseases and disorders are also provided.

L'invention concerne des polypeptides variants de récepteurs solubles d'activine IIB et des protéines pouvant se lier aux activités de l'activine A, de la myostatine, ou du GDF-11 et les d'inhiber. La présente invention concerne également des polynucléotides, des vecteurs et des cellules hôtes pouvant produire les polypeptides variants et les protéines. Des compositions et des procédés pour traiter l'atrophie musculaire ainsi que d'autres maladies et troubles sont également fournis.

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