C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/24 (2006.01) C07K 16/00 (2006.01) C12N 15/13 (2006.01)
Patent
CA 2733742
The present invention relates to domain antibodies which have modified framework regions such that the potency or level of binding of the domain antibody is improved. In particular the present invention relates to domain antibodies which bind TNF.alpha. in which changes have been made to framework sequences and to constructs including these domain antibodies.
La présente invention concerne des anticorps de domaines qui ont des régions charpentes modifiées de façon à améliorer la puissance ou le niveau de liaison de l'anticorps de domaine. En particulier, la présente invention concerne des anticorps de domaines qui se lient au TNFa dans lesquels des changements ont été effectués, au niveau des séquences charpentes et des constructions génétiques comprenant ces anticorps de domaines.
Clarke Adam William
Doyle Anthony Gerard
Elgundi Zehra
Gay Robert Daniel
Jennings Philip Anthony
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Cephalon Australia Pty Ltd
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