Variant target binding agents and uses thereof

Details Variant target binding agents and uses thereof Variant target binding agents and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2699837

The present invention provides variant target binding agents and methods relating to the use of such binding agents for the prophylaxis or treatment of cancers and immunological disorders. The variant target binding agent is conjugated to a thera-peutic agent that exerts a cytotoxic, cytostatic, or immunomodulatory effect on target cells.

L'invention concerne des agents se liant à des cibles variables et des procédés liés à l'utilisation de tels agents de liaison pour la prophylaxie et le traitement de cancers et de troubles immunologiques. L'agent se liant à des cibles variables est conjugué à un agent thérapeutique qui exerce un effet cytotoxique, cytostatique ou immunomodulateur sur des cellules cibles.

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