Variant type ii tgf-beta receptor fusion proteins and methods

Details Variant type ii tgf-beta receptor fusion proteins and methods Variant type ii tgf-beta receptor fusion proteins and methods

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 38/17 (2006.01) C07K 14/71 (2006.01) C12N 15/62 (2006.01) C12N 15/85 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2330939

Fusion proteins comprising a variant form of TGF-beta Type II receptor linked to a portion of an immunoglobulin constant chain are described. Also described are methods of using the fusion proteins of the invention to treat a variety of fibroproliferative disorders.

L'invention concerne des protéines de fusion comprenant une forme d'un variant du récepteur du type II du TGF-bêta, liée à une partie d'une chaîne constante d'immunoglobuline. Cette invention concerne également des méthodes d'utilisation de ces protéines de fusion, ces méthodes permettant de traiter un grand nombre d'affections fibronéoplastiques.

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