Variants of activin iib receptor polypeptides and uses thereof

Details Variants of activin iib receptor polypeptides and uses thereof Variants of activin iib receptor polypeptides and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 14/705 (2006.01) C07K 14/71 (2006.01) C07K 14/72 (2006.01)

Patent

CA 2743850

The present invention provides stabilized activin IIB receptor polypeptides and proteins capable of binding and in-hibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the stabilized polypeptides and proteins. Compositions and methods for treating muscle-wasting dis-eases and metabolic disorders are also provided.

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