Variants of bile salt-stimulated lipase, dna molecules...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/55 (2006.01) A01K 67/027 (2006.01) A23C 9/152 (2006.01) A23C 9/20 (2006.01) A23L 1/305 (2006.01) A61K 38/46 (2006.01) A61P 1/00 (2006.01) A61P 3/00 (2006.01) A61P 11/00 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 9/20 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01)

Patent

CA 2156083

The present invention relates to novel polypeptides which are variants of Bile Salt-Stimulated Lipase (BSSL; EC 3.1.1.1). It also relates to DNA molecules encoding the said polypeptides, and to subproducts comprising the said DNA molecules. The invention further relates to processes for producing the said BSSL variants and for producing transgenic non-human mammals capable of expressing the BSSL variants. Furthermore the invention relates to such transgenic animals as well as to infant formulas comprising milk from such transgenic animals. The invention also relates to pharmaceutical compositions comprising the said polypeptides; and the use of the said polypeptides and DNA molecules for the manufacture of medicaments.

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