C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/575 (2006.01) A61K 38/00 (2006.01) A61K 38/17 (2006.01) A61P 9/00 (2006.01) A61P 19/00 (2006.01) C12N 15/00 (2006.01) C12P 21/02 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2758581
The present disclosure provides variants of C-type natriuretic peptide (CNP), pharmaceutical compositions com-prising CNP variants, and methods of making CNP variants. The CNP variants are useful as therapeutic agents for the treatment of diseases responsive to CNP, including but not limited to bone-related disorders, such as skeletal dysplasias (e.g., achondroplasia), and vascular smooth muscle disorders (e.g., restenosis and arteriosclerosis).
La présente invention concerne des variants du peptide natriurétique de type (CNP), des compositions pharmaceutiques comprenant les variants du CNP, et des méthodes de fabrication de variants du CNP. Les variants du CNP sont utiles comme agents thérapeutiques pour le traitement de maladies répondant au CNP, comprenant entre autres les pathologies osseuses, telles que les dysplasies du squelette (par exemple l'achondroplasie), et les troubles des muscles lisses vasculaires (par exemple la resténose et l'artériosclérose).
Aoyagi-Scharber Mika
Castillo Sianna
Long Shinong
Okhamafe Augustus O.
Price Christopher P.
Biomarin Pharmaceutical Inc.
Smart & Biggar
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