Variants of c-type natriuretic peptide

Details Variants of c-type natriuretic peptide Variants of c-type natriuretic peptide

C - Chemistry, Metallurgy

07

K

C07K 14/58 (2006.01) A61K 38/22 (2006.01)

Patent

CA 2705603

The present invention provides variants of C-type natriuretic peptide (CNP) comprising one or more deletions; additions of and/or substitutions with natural amino acids, unnatural amino acids and/or peptidomimetics (including peptide bond isosteres); amino acid extensions; and/or other chemical moieties such as, e.g., poly(ethylene glycol) and hydrophobic acids. The CNP variants are useful as therapeutic agents for the treatment of diseases responsive to CNP, including but not limited to bone-related disorders sucli as, e.g., skeletal dysplasias and achondroplasia, and vascular smooth muscle disorders such as, e.g., restenosis and arteriosclerosis.

L'invention concerne des variantes de peptide natriurétique de type C (CNP) comprenant une ou plusieurs délétions, additions et/ou substitutions avec des acides aminés naturels, des acides aminés non naturels et/ou des substances peptidomimétiques (y compris des isostères de liaison peptidique); des extensions d'acides aminés; et/ou d'autres fractions chimiques telles que, par exemple, le poly(éthylène glycol) et les acides hydrophobes. Les variantes de CNP sont utiles comme agents thérapeutiques pour le traitement de maladies réactives au CNP, y compris, sans s'y limiter, les troubles liés aux os tels que, par exemple, les dysplasies squelettiques et l'achondroplasie, et les troubles des muscles lisses vasculaires tels que, par exemple, la resténose et l'artériosclérose.

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