Variants of group 1 allergens from poaceae having reduced...

Details Variants of group 1 allergens from poaceae having reduced... Variants of group 1 allergens from poaceae having reduced...

C - Chemistry, Metallurgy

07

K

C07K 14/415 (2006.01)

Patent

CA 2574449

The invention relates to the production and use of variants of group 1 allergens of Poaceae (sweet-grass), which are characterised by a reduced IgE reactivity compared to the known wild-type allergens and a largely maintained reactivity to T-lymphocytes. Said hypoallergenic allergen variants can be used for the specific immunotherapy (hyposensitivity) of patients suffering from grass pollen allergies or for the preventive immunotherapy of grass pollen allergies.

L'invention concerne la fabrication et l'utilisation de variants des allergènes du groupe 1 issus de poaceae (graminacées) présentant une réactivité à IgE réduite par rapport aux allergènes de type sauvage connus ainsi qu'une réactivité aux lymphocytes T essentiellement conservée. Lesdits variants d'allergènes hypoallergéniques peuvent être employés dans la thérapie immunitaire spécifique (hyposensibilisation) de patients souffrant d'une allergie aux pollens de graminacées ou dans la thérapie immunitaire préventive d'allergies aux pollens de graminacées.

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