C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/475 (2006.01) A61K 38/18 (2006.01) A61P 25/28 (2006.01) C07K 14/48 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2260296
The variants of human ciliary neurotrophic factor (hCNTF) according to the present invention are characterised by substitution of phenylalanine 152 and/or of lysine 155 with alanine. These variants have biological properties that render them important as the active principles of drugs for the treatment of diseases and pathologies involving the nervous system or other pathologies involving cells responding to the CNTF. Figure 2 shows the results of stimulation of haptoglobin secretion from HepG2 cells by CNTF and the variants described in the invention.
Variants de facteur neurotrophique ciliaire humain caractérisés par la substitution de phénylalanine 152 et/ou de lysine 155 par alanine. Ces variants possèdent des propriétés biologiques qui les rendent importants en tant que principaux principes actifs de médicaments pour le traitement de maladies et de pathologies touchant le système nerveux ou d'autres pathologies touchant la réponse des cellules au CNTF. La figure 2 montre les résultats de la stimulation de la sécrétion d'haptoglobine de cellules HepG2 par le CNTF et les variants décrits dans la présente invention.
Di Marco Annalise
Laufer Ralph
Fetherstonhaugh & Co.
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.p.a.
LandOfFree
Variants of human ciliary neurotrophic factor (hcntf) with a... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Variants of human ciliary neurotrophic factor (hcntf) with a..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Variants of human ciliary neurotrophic factor (hcntf) with a... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-2067022