C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/59 (2006.01) A61K 38/00 (2006.01) C07K 16/00 (2006.01) C12N 15/00 (2006.01)
Patent
CA 2545160
The present invention provides human glycoprotein hormone (hGPH) &-chain splice variants, including isolated nucleic acids encoding these variants and the encoded amino avid sequences, as well as antibodies, antisense oligonucleotides, expression vectors and host cells comprising these sequences. The present invention further discloses the use of these sequences in the diagnosis, prevention and treatment of symptoms, diseases and disorders related to glycoprotein hormones.
L'invention concerne des variants d'épissage de la chaîne .alpha. de l'hormone glycoprotéine humaine, y compris des acides nucléiques isolés codant ces variants et les séquences d'acides nucléiques codées, ainsi que des anticorps, des oligonucléotides antisens, des vecteurs d'expression et des cellules hôtes comprenant ces séquences. L'invention concerne en outre l'utilisation de ces séquences dans le diagnostic, la prévention et le traitement de symptômes, de maladies et de troubles associés aux hormones glycoprotéines.
Baum Gideon
Bernstein Jeanne
Dahary Dvir
Shaaltiel Yoseph
Shalev Gil
Compugen Ltd.
Protalix Ltd.
Ridout & Maybee Llp
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