Variants of immunoglobulin gene superfamily member

Details Variants of immunoglobulin gene superfamily member Variants of immunoglobulin gene superfamily member

A - Human Necessities

61

K

530/13, 195/1.22

A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 14/34 (2006.01) C07K 14/73 (2006.01) C07K 16/00 (2006.01) C12N 15/12 (2006.01) C12P 21/02 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1341427

Novel derivatives of cell surface proteins which are homologous to the immunoglobulin superfamily (adhesons) are provided. Amino acid sequence variations are introduced into adheson, the most noteworthy of which are those in which the transmembrane and, preferably, cytoplasmic domains are rendered functionally inactive, and in which adheson extracellular domains replace an immunoglobulin variable region. These variants are useful in therapy or diagnostics, in particular, CD4 variants are therapeutically useful in the treatment of HIV infections.

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