Variants of the extracellular domain of bcma and uses thereof

Details Variants of the extracellular domain of bcma and uses thereof Variants of the extracellular domain of bcma and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 14/705 (2006.01) A61K 38/00 (2006.01) C12N 15/12 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2554526

The present invention relates to polypeptides that inhibit APRIL and/or BAFF binding to BCMA, nucleic acid molecules encoding the polypeptides, and compositions comprising the polypeptides. The present invention also relates to methods for treating an immune-related disease or cancer using the polypeptides and compositions of the invention. The present invention also relates to methods for identifying inhibitors of APRIL/BAFF binding to BCMA and APRIL/BAFF signaling.

L'invention concerne des polypeptides qui inhibent la liaison de APRIL et/ou de BAFF avec BCMA, de molécules d'acide nucléique codant pour ces polypeptides, et des compositions contenant ces polypeptides. L'invention concerne également des méthodes de traitement d'une maladie d'origine immunitaire ou d'un cancer, comprenant l'administration des polypeptides et des compositions décrits. L'invention se rapporte en outre à des procédés permettant d'identifier des inhibiteurs de la liaison de APRIL/BAFF avec BCMA, et de la signalisation de APRIL/BAFF.

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