Variants of thymidine kinase, related nucleic acids...

Details Variants of thymidine kinase, related nucleic acids... Variants of thymidine kinase, related nucleic acids...

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) A61K 31/70 (2006.01) A61K 38/45 (2006.01) A61K 48/00 (2006.01) C12N 9/12 (2006.01)

Patent

CA 2245508

The present invention relates to a nucleic acid sequence characterized in that it is derived from the wild nucleic acid sequence coding for a thymidine kinase, said nucleic acid sequence having at least one mutation in the region corresponding to the ATP binding site and conveniently a second mutation in the N-terminal region and/or C-terminal region. It also relates to variants of the wild thymidine kinase and their uses in genic therapy.

La présente invention se rapporte à une séquence d'acides nucléiques caractérisée en ce qu'elle dérive de la séquence d'acides nucléiques sauvage codant pour une thymidine kinase, ladite séquence d'acides nucléiques possédant au moins une mutation dans la région correspondant au site de liaison à l'ATP et avantageusement une deuxième mutation dans la région N- terminale et/ou la région C-terminale. Elle concerne en outre des variants de la thymidine kinase sauvage et leurs utilisations en thérapie génique.

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