Variants of traf2 which act as an inhibitor of tnf-alpha...

C - Chemistry – Metallurgy – 12 – N

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C12N 15/12 (2006.01) A61K 38/16 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/435 (2006.01) C07K 14/715 (2006.01) C12N 15/63 (2006.01) C12N 15/64 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2372803

The present invention relates to variants of TRAF2 which demonstrate the ability to inhibit the TNF .alpha. signaling pathway. In particular, applicants have isolated a splice variant of TRAF2 referred to hereinafter as "TRAF2 truncated" or "TRAF2TR" and a TRAF2 expression construct with enhanced dominant negative properties, hereafter referred to as "TRAF2 truncated- deleted" or "TRAF2TD". Both TRAF2TR and TRAF2TD have the ability to inhibit the TNF .alpha. signaling pathway and in TRAF2TD, this ability is greatly enhanced, greatly reducing the response to TNF .alpha. binding.

La présente invention concerne des variantes de TRAF2 qui manifestent la capacité d'inhiber la voie de signalisation TNF .alpha.; les déposants ont notamment isolé une variante épissée de TRAF2 ci-après dénommée "TRAF2 tronqué" ou "TRAF2TR" et une structure d'expression de TRAF2 avec des propriétés négatives dominantes renforcées, ci-après dénommée "TRAF2 tronqué-délété" ou "TRAF2TD". Le facteur TRAF2TR tout comme celui TRAF2TD ont la capacité d'inhiber la voie de signalisation TNF .alpha.; dans TRAF2TD, cette capacité a été fortement augmentée, ce qui réduit la réponse à la liaison de TNF .alpha..

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

Variants of traf2 which act as an inhibitor of tnf-alpha... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Variants of traf2 which act as an inhibitor of tnf-alpha..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Variants of traf2 which act as an inhibitor of tnf-alpha... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-1665325

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.