C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/16 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/435 (2006.01) C07K 14/715 (2006.01) C12N 15/63 (2006.01) C12N 15/64 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2372803
The present invention relates to variants of TRAF2 which demonstrate the ability to inhibit the TNF .alpha. signaling pathway. In particular, applicants have isolated a splice variant of TRAF2 referred to hereinafter as "TRAF2 truncated" or "TRAF2TR" and a TRAF2 expression construct with enhanced dominant negative properties, hereafter referred to as "TRAF2 truncated- deleted" or "TRAF2TD". Both TRAF2TR and TRAF2TD have the ability to inhibit the TNF .alpha. signaling pathway and in TRAF2TD, this ability is greatly enhanced, greatly reducing the response to TNF .alpha. binding.
La présente invention concerne des variantes de TRAF2 qui manifestent la capacité d'inhiber la voie de signalisation TNF .alpha.; les déposants ont notamment isolé une variante épissée de TRAF2 ci-après dénommée "TRAF2 tronqué" ou "TRAF2TR" et une structure d'expression de TRAF2 avec des propriétés négatives dominantes renforcées, ci-après dénommée "TRAF2 tronqué-délété" ou "TRAF2TD". Le facteur TRAF2TR tout comme celui TRAF2TD ont la capacité d'inhiber la voie de signalisation TNF .alpha.; dans TRAF2TD, cette capacité a été fortement augmentée, ce qui réduit la réponse à la liaison de TNF .alpha..
Clark Kenneth L.
Guo Kun
Ivashchenko Yuri D.
Pagnoni Marco F.
Searfoss George H. III
Aventis Pharmaceuticals Inc.
Aventis Pharmaceuticals Products Inc.
Deeth Williams Wall Llp
LandOfFree
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