C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/18 (2006.01) A61K 38/18 (2006.01) C07K 14/515 (2006.01) C07K 14/52 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2280209
Disclosed are vascular endothelial cell growth factor variants having a C- terminus heparin binding domain modification, as well as all associated recombinant technology including DNA encoding such variants, transformed host cells and methods for preparing such variants. These variants are described as having altered binding characteristics such that the variant has a reduced clearance rate compared with native material.
L'invention concerne des variants du facteur de croissance des cellules endothéliales vasculaires qui présentent une modification du domaine fixant l'héparine en extrémité C. L'invention concerne en outre l'ensemble de la technologie de recombinaison associée, y compris l'ADN codant lesdits variants, et aussi des cellules hôtes transformées et des procédés relatifs à l'élaboration de ces variants. On a modifié les caractéristiques de liaison des variants en question dans le but de conférer aux variants un taux d'élimination réduit par rapport au matériau naturel.
Deguzman Geralyn G.
Keck Rodney G.
Modi Nishit B.
Richard Brigitte M.
Zioncheck Thomas F.
Dennison Associates
Genentech Inc.
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