C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/71 (2006.01) C07K 16/28 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2673222
An isolated polypeptide variant of VEGFR comprising an amino acid sequence at least 70 % homologous to SEQ ID NO: 4 and an isolated polynucleotide encoding same are disclosed. A polynucleotide comprising a nucleic acid sequence capable of specifically hybridizing to the isolated polynucleotide and an isolated antibody comprising an antigen recognition domain which specifically binds the isolated polypeptide are also disclosed. Pharmaceutical compositions, methods of diagnosing and treating comprising same are also disclosed.
L'invention concerne un variant polypeptidique isolé de VEGFR comprenant une séquence d'acides aminés à au moins 70 % homologue à SEQ ID N°: 4 et un polypeptide isolé codant pour celui-ci. L'invention concerne également un polynucléotide comprenant une séquence d'acide nucléique capable de s'hybrider spécifiquement au polynucléotide isolé et un anticorps isolé comprenant un domaine de reconnaissance d'antigène qui se lie spécifiquement au polypeptide isolé. L'invention concerne en outre des compositions pharmaceutiques, des procédés de diagnostic et de traitement comprenant celles-ci.
Itin Ahuva
Keshet Eli
Sela Shay
Yagel Simcha
Hadasit Medical Research Services And Development Ltd.
Integral Ip
Yissum Research Development Company Of The Hebrew University Of
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