Vascular aging-predicting factor and utilization of the same

C - Chemistry – Metallurgy – 07 – K

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C07K 14/47 (2006.01) C07K 16/18 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2631222

It is intended to provide a factor which predicts vascular aging and a method of examining an early lesion caused by vascular aging. More specifically speaking, it is intended to provide: a factor predicting vascular aging which comprises human apolipoprotein B100 having a glutathionated thiol group; a method of examining a lesion caused by vascular aging which comprises measuring human apolipoprotein B100 having a glutathionated thiol group in a blood sample; an antibody capable of specifically recognizing apolipoprotein B100 having a glutathionated thiol group; and a diagnostic or a diagnostic kit for an early lesion caused by vascular aging which contains an antibody capable of recognizing human apolipoprotein B100 having a glutathionated thiol group.

L'invention concerne un facteur qui prédit le vieillissement vasculaire et un procédé d'examen d'une lésion précoce provoquée par le vieillissement vasculaire. Plus précisément, l'invention concerne : un facteur de prédiction du vieillissement vasculaire lequel comprend l'apolipoprotéine B100 humaine ayant un groupe thiol lié à un glutathion ; un procédé d'examen d'une lésion provoquée par le vieillissement vasculaire lequel comprend de mesurer le niveau de l'apolipoprotéine B100 humaine ayant un groupe thiol lié à un glutathion dans un échantillon sanguin ; un anticorps capable de reconnaître spécifiquement l'apolipoprotéine B100 ayant un groupe thiol lié à un glutathion ; et un diagnostic ou un kit de diagnostic pour une lésion précoce provoquée par le vieillissement vasculaire lequel contient un anticorps capable de reconnaître l'apolipoprotéine B100 humaine ayant un groupe thiol lié à un glutathion.

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