Vascular endothelial growth factor-b

Details Vascular endothelial growth factor-b Vascular endothelial growth factor-b

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 31/70 (2006.01) A61K 38/18 (2006.01) A61K 39/395 (2006.01) C07K 14/49 (2006.01) C07K 14/52 (2006.01) C07K 16/22 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2211687

VEGF-B polypeptides from the PDGF family of growth factors having the property of promoting mitosis and proliferation of vascular endothelial cells, DNA sequences encoding these polypeptides, pharmaceutical compositions containing them and antibodies which react with them. The VEGF-B polypeptides are useful in stimulating angiogenesis as well as in diagnostic applications.

Cette invention concerne des polypeptides VEGF-B (facteur de croissance-B des cellules endothéliales vasculaires) de la famille des facteurs de croissance PDGF (facteur mitogénique plaquettaire), ces polypeptides ayant la propriété de stimuler la mitose et la prolifération des cellules endothéliales vasculaires. Elle concerne également des séquences d'ADN codant ces polypeptides, des compositions pharmaceutiques les contenant, ainsi que des anticorps qui réagissent avec eux. Ces polypeptides VEGF-B sont utiles pour stimuler l'angiogénèse et servent, en outre, à des applications de diagnostic.

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