A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61K 38/16 (2006.01) A61K 47/42 (2006.01) A61P 19/10 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2527984
The 121-amino acid isoform of vascular endothelial growth factor (VEGF121) is linked by a flexible G4S tether to a cytotoxic molecule such as toxin gelonin or granzyme B and expressed as a soluble fusion protein. The VEGF121 fusion protein exhibits significant anti-tumor vascular-ablative effects that inhibit the growth of primary tumors and inhibit metastatic spread and vascularization of metastases. The VEGF121 fusion protein may also target osteoclast precursor cells in vivo and inhibits osteoclastogenesis.
L'invention concerne une isoforme d'acide aminé 121 de facteur de croissance endothéliale vasculaire (VEGF¿121?) reliée par une liaison G4S flexible à une molécule cytotoxique de type toxine gélonine ou granzyme B et exprimée en tant que protéine de fusion soluble. La protéine de fusion VEGF¿121? produit des effets antitumoraux vasculaires ablatifs notables qui inhibent la croissance de tumeurs primaires ainsi que le développement métastatique et la vascularisation de métastases. Ladite protéine de fusion VEGF¿121? peut également cibler des cellules précurseurs des ostéoclastes in vivo et inhibe l'ostéoclastogenèse.
Goudreau Gage Dubuc
Research Development Foundation
LandOfFree
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