Vascular endothelial growth factor variants

Details Vascular endothelial growth factor variants Vascular endothelial growth factor variants

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/18 (2006.01) C07K 14/52 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2373822

The invention is directed to a method of enhancing the biological activity of vascular endothelial growth factors (VEGF). The invention further concerns certain VEGF variants having enhanced biological activity, methods and means for preparing these variants, and pharmaceutical compositions comprising them. In a further aspect, the invention concerns methods of treatment using, and articles of manufacture containing such VEGF variants.

L'invention se rapporte à une méthode visant à accroître l'activité biologique des facteurs de croissance endothéliale. Elle se rapporte notamment à certains variants des VEGF qui présentent une activité biologique accrue, à des méthodes et unités de préparation ces variants et à des compositions pharmaceutiques contenant ces variants. Dans une autre réalisation, l'invention se rapporte à des méthodes de traitement mettant en oeuvre ces variants et à des produits manufacturés les contenant.

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