Vascular endothelial growth factor-x

Details Vascular endothelial growth factor-x Vascular endothelial growth factor-x

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 31/70 (2006.01) A61K 38/18 (2006.01) A61K 39/395 (2006.01) A61P 9/00 (2006.01) C07K 14/52 (2006.01) C07K 16/22 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) G01N 33/50 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2356009

There is provided a novel vascular endothelial growth factor, herein designated VEGF-X, in addition to the nucleic acid molecule encoding it, a host cell transformed with said vector and compounds which inhibit or enhance angiogenesis. Also provided is the sequence of a CUB domain present in the sequence of VEGF-X which domain itself prevents angiogenesis and which is used to treat diseases associated with inappropriate vascularisation or angiogenesis.

L'invention se rapporte à un nouveau facteur de croissance endothéliale vasculaire, désigné ci-après VEGF-X, à la molécule d'acide nucléique qui code pour ce facteur, à une cellule hôte transformée avec ledit vecteur et à des composés qui inhibent ou stimulent l'angiogenèse. L'invention se rapporte également à la séquence d'un domaine CUB présent dans la séquence du VEGF-X. Ledit domaine empêche l'angiogenèse et permet de traiter des maladies associées à une vascularisation incorrecte ou une angiogenèse.

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