Vascular grafts with fatty acid salts of aminoglycoside...

A - Human Necessities – 61 – L

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A61L 33/04 (2006.01) A61L 27/16 (2006.01) A61L 27/18 (2006.01) A61L 27/54 (2006.01) A61L 33/10 (2006.01)

Patent

CA 2582011

One or more substances of the group consisting of gentamicin palmitate, gentamicin myristate, gentamicin laurate, tobramycin palmitate, tobramycin myristate, tobramycin laurate, amikacin palmitate, amikacin myristate, amikacin laurate, vancomycin palmitate, vancomycin laurate, and vancomycin myristate are suitable for providing vascular grafts with an antithrombogenically ac-tive principle. The appropriate method for providing vascular grafts with an antithrombogenically active principle particularly comprises the following steps of immersing the graft body A in an alcoholic solution or an alcoholic solution with a readily volatile solvent, such as chloro-form, of a member of the group consisting of gentamicin palmitate, gentamicin myristate, gentamicin laurate, tobramycin palmitate, tobramycin myristate, tobramycin laurate, amikacin palmitate, amikacin myristate, amikacin laurate, vancomycin palmitate, and vancomycin myristate, or of spraying said solution on said graft body, and of B vaporizing said alcoholic solvent.

L'invention porte sur une ou plusieurs substances parmi les suivantes : palmitate de gentamicine, myristate de gentamicine, laurate de gentamicine, palmitate de tobramycine, myristate de tobramycine, laurate de tobramycine, palmitate d'amikacine, myristate d'amikacine, laurate d'amikacine, palmitate de vancomycine, laurate de vancomycine et myristate de vancomycine. Ces substances peuvent constituer un principe actif antithrombogénique pour les greffons vasculaires. La méthode permettant aux greffons vasculaires de bénéficier des effets d'un principe actif antithrombogénique comprend plus particulièrement les étapes suivantes : immersion du greffon A) dans une solution d'alcool ou une solution d'alcool contenant un solvant très volatile, par exemple le chloroforme, dans laquelle est dissout du palmitate de gentamicine, du myristate de gentamicine, du laurate de gentamicine, du palmitate de tobramycine, du myristate de tobramycine, du laurate de tobramycine, du palmitate d'amikacine, du myristate d'amikacine, du laurate d'amikacine, du palmitate de vancomycine, du laurate de vancomycine ou du myristate de vancomycine, ou vaporisation de ladite solution sur ledit greffon, et B) vaporisation dudit solvant à base d'alcool.

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