A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
3/121, 117/69
A61L 27/16 (2006.01) A61L 27/34 (2006.01) A61L 33/00 (2006.01)
Patent
CA 1110402
ABSTRACT OF THE DISCLOSURE A vascular prosthesis and a process for preparing the same are disclosed, which vascular prosthesis has a composite structure of a porous tubing of polytetrafluoroethylene with polyethyleneimine in the pores of the tubing, the polyethylene- imine being water-solubilzed with the amino groups quaternized and having heparin ionically bound thereto. According to this invention, a microstructure composed of fibers and nodes which is obtained by stretching a tubing of polytetrafluoroethylene in at least one axial direction and heating the stretched tubing to at least 327°C is used as one starting material. Then, the pores of the microstructure are filled, with a solution of polyethyleneimine and the polyethyleneimine is subjected to a water-insolubilization treatment and a quaternization treatment. Then, heparin is ionically bound to the polyethyleneimine to form a composite structure. Thus, the invention provides a vascular prosthesis having a high rate of patency which permits a thin neointima to form on the inner surface of the prosthesis after implantation with sufficient nutrition being provided the neointima thereby to retain a neointima without degenerative change and without occulsion of the interior cavity of the prosthesis.
306564
George H. Riches And Associates
Sumitomo Electric Industries Ltd.
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